There are currently 22 local United Ways serving the communities of South Carolina.
- United Way of Aiken County, Inc.
- United Way of Anderson County
- Barnwell County United Way (Allendale, Bamberg, Barnwell Counties)
- Black River United Way (Georgetown and Williamsburg Counties)
- United Way of Chester County
- United Way of Chesterfield County
- United Way of Florence County
- United Way of Greenville County
- United Way of Greater Hartsville (Darlington County)
- United Way of Horry County
- United Way of Kershaw County
- United Way of the Lakelands (Abbeville, Greenwood, McCormick, and Saluda Counties)
- United Way of Lancaster County
- United Way of Laurens County
- United Way of the Lowcountry, Inc. (Beaufort and Jasper Counties)
- United Way of the Midlands (Calhoun, Fairfield, Lexington, Newberry, Orangeburg, and Richland Counties)
- United Way of Oconee County
- United Way of Pickens County
- United Way of the Piedmont (Cherokee, Spartanburg, and Union Counties)
- United Way of Sumter, Clarendon and Lee Counties
- Trident United Way (Berkeley, Charleston, and Dorchester Counties)
- United Way of York County